Progress of inhibitory effect of medicinal plant extracts on calcineurin

Authors He Na; Wu Pengfei; Cui Zhifeng

Journal Chinese Journal of Pharmacology and Toxicology , 2014,3:28

Abstract Calcineurin inhibitors,such as cyclosporin A and tacrolimus,are widely-used immunosuppressive drugs clinically. However,renal toxicity,hyperglycaemia and other side-effects can occur over long-term use. Isolation of novel calcineurin inhibitors from medicinal plants in recent years has provided a new approach to the development of new immunosuppressive drugs with high efficiency and low toxicity. Recnt studies have shown that medicinal plant extracts,such as isogarcinol,quercetin,kaempferol, phenylethanoid glycosides,eremophilane sesquiterpenes A and B,pisiferdiol,as well as extracts from Smilax china L and Jasminum humile L,have obvious inhibitory effect on calcineurin.

Species covered 菝葜 Smilax china 矮探春 Jasminum humile