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Two new cholinesterase inhibitors asiatoates A and B from Buddleja asiatica

Authors Ali, Farman; Khan, Hidayat Ullah; Afzal, Masood; Samad, Abdul; Khan, Shafi Ullah; Ali, Irshad

Journal JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH , JUN 1 2013,6:15

DOI 10.1080/10286020.2013.794417 PubMed 23659547

Abstract Two new benzoates, asiatoate A (1) and asiatoate B (2), have been isolated from the ethyl acetate soluble fraction of Buddleja asiatica whole plant. Their structures were elucidated with the help of spectroscopic data. Both showed significant inhibitory effect on acetylcholinesterase (AChE) and butylcholinesterase (BChE) in a dose-dependent manner. The IC50 values of compounds 1-2 were 5.54 and 8.34M against AChE while 30.94 and 35.94M against BChE, respectively.

Species covered 七里香 Buddleja asiatica