Rapid and sensitive screening of antifungal activity in medicinal plants by a single-cell biosensing system

Authors Oh, KB; Iida, Y; Matsuoka, H; Kurata, H

Journal BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY , MAY 1996,5:60

DOI 10.1271/bbb.60.911 PubMed 8704324

Abstract A biosensing system based on the response of fungal cells was used for the evaluation of antifungal activity of medicinal plants against Aspergillus niger. This system measured the hyphal growth rate in real time in the presence or absence of Chinese herbal extracts. The sensitivity of this system was 100-fold higher than that of conventional methods, and is advisable for the screening of antifungal compounds.