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beta-Resorcylic acid derivatives with alpha-glucosidase inhibitory activity from Lasiodiplodia sp ZJ-HQ(1), an endophytic fungus in the medicinal plant Acanthus ilicifolius

Authors Chen, Senhua; Liu, Zhaoming; Li, Hanxiang; Xia, Guoping; Lu, Yongjun; He, Lei; Huang, Shaodong; She, Zhigang

Journal PHYTOCHEMISTRY LETTERS , SEP 2015,:13

DOI 10.1016/j.phytol.2015.05.019

Abstract Three new beta-resorcylic acid derivatives, compounds 1-3, along with six known analogues (4-9) were isolated from an endophytic fungus Lasiodiplodia sp. ZJ-HQ(1) derived from medicinal plant Acanthus ilicifolius. Their structures were elucidated by 1D and 2D NMR spectroscopic analysis, high resolution mass spectrometric (HREIMS) data, and X-ray crystallography. The absolute configurations of compounds 1 and 2 were determined by the modified Mosher''s method. Compounds 1-7 showed more potent inhibitory effects against a-glucosidase activity than the clinical alpha-glucosidase inhibitor acarbose. (C) 2015 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.

Species covered 老鼠簕 Acanthus ilicifolius