Antifungal Proteins with Antiproliferative Activity on Cancer Cells and HIV-1 Enzyme Inhibitory Activity from Medicinal Plants and Medicinal Fungi

Authors Wong, Jack Ho; Ng, Tzi Bun; Wang, Hexiang; Cheung, Randy Chi Fai; Ng, Charlene Cheuk Wing; Ye, Xiuyun; Yang, Jie; Liu, Fang; Ling, Chen; Chan, Ki; Ye, Xiujuan; Chan, Wai Yee

Journal CURRENT PROTEIN & PEPTIDE SCIENCE , 2019,3:20

DOI 10.2174/1389203719666180613085704 PubMed 29895244

Abstract A variety of fungi, plants, and their different tissues are used in Traditional Chinese Medicine to improve health, and some of them are recommended for dietary therapy. Many of these plants and fungi contain antifungal proteins and peptides which suppress spore germination and hyphal growth in phytopathogenic fungi. The aim of this article is to review antifungal proteins produced by medicinal plants and fungi used in Chinese medicine which also possess anticancer and Human Immunodeficiency Virus-1 (HIV-1) enzyme inhibitory activities.