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Protective Effect of Some Medicinal Plants on tert-Butyl Hydroperoxide-Induced Oxidative Stress in Human Keratinocytes

Authors MinKyun, Na，; ???; ???; ???; ???

Journal Natural Product Sciences , JUN 2019,3:46

DOI 10.1007/s11033-019-04730-w PubMed 30977084

Abstract It is well known that excessive production of reactive oxygen species (ROS) leads to oxidative stress,loss of cell function, and ultimately apoptosis or necrosis. To search for natural antioxidants able to modulatecellular oxidative stress, we investigated the protective effect of ethanol extracts of 17 medicinal plants selectedfrom the preliminary antioxidant screening on tert-butyl hydroperoxide (t-BuOOH)-induced oxidative stress inhuman keratinocytes. The result showed that extracts of the four plants, Distylium racemosum, Astilbe chinensis,Cercis chinensis and Sapium japonicum, exhibited significant cytoprotective activity (over 50% protection)against t-BuOOH-induced cellular injury.

Species covered 紫荆(原变型) Cercis chinensis 白木乌桕 Sapium japonicum 落新妇 Astilbe chinensis