Inhibition of mouse ear edema by steroidal and triterpenoid saponins

Authors Kim, SY; Son, KH; Chang, HW; Kang, SS; Kim, HP

Journal ARCHIVES OF PHARMACAL RESEARCH , JUN 1999,3:22

DOI 10.1007/BF02976370 PubMed 10403138

Abstract Certain steroids and triterpenoids isolated from diverse plant families were known to possess anti-inflammatory activity. In the course of finding new anti-inflammatory natural products, some steroidal and triterpenoid saponins were isolated and evaluated for their anti-inflammatory activity using in vivo mouse ear edema tea At the oral dose of 100 mg/kg, several steroidal saponins and triterpenoid saponins such as hederagenin glycosides st-cowed significant inhibition of ear edema (20 similar to 37% inhibition), though less potent than indomethacin and hydrocortisone.