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Effect of lipid-based suspension of Epimedium koreanum Nakai extract on sexual behavior in rats

作者 Makarova, Marina N.; Pozharitskaya, Olga N.; Shikov, Alexander N.; Tesakova, Svetlana V.; Makarov, Valery G.; Tikhonov, Vladirnir P.

期刊 JOURNAL OF ETHNOPHARMACOLOGY , DEC 3 2007,3:114

DOI 10.1016/j.jep.2007.08.021 PubMed 17890032

摘要 Ethnopharmacological relevance: Herba of Epimedium koreanum is used in traditional Chinese and Korean herbal medicine as a potent enhancer of erectile function. Icariin, the main active component of Epimedium koreanum, possesses many biological effects, such as improving cardiovascular function, hormone regulation, immunological function modulation, and anti-tumor activity.Aim of the Study: This study supports the traditional use of extracts from Epimedium species in erectile dysfunction.Materials and Methods: The Epimedium koreanum dry extract was suspended in wheat germ oil using lecithin and bee wax for oral administration. The effect of oral administration of two compositions (E-01 and E-02) standardized by their icariin content on the number of complete intromissions, the number of ejaculations, and the latent period of ejaculation (LPE) in rats were evaluated. E-01 and E-02 were administered orally for 10 days to the experimental animals. The control animals received olive oil for 10 days. On day 10, 0.5 h after the dose was administered to male rats, one virgin female rat was placed with one male rat.Results: The number of complete intromissions increased to 23.3 +/- 2.6 in the E-01 and E-02 group (dose 300 mg/kg body weight) (b.wt) and to 20.1 +/- 2.3 in the E-02 group (dose 750 mg/kg b.wt) compared with 15.2 +/- 2.4 in the control group of aged rats. The number of ejaculations increased from 1.1 +/- 0.3 in the control-aged group to 2.6 +/- 0.4 in the E-01 group. The LPE of male rats was 14.2 +/- 1.8 min in the control-aged group. The LPE of the aged group was reduced to 9.8 +/- 1.5 min, 9.8 +/- 1.6 min, and 11.4 +/- 1.8 min when treated with E-01 at a dose of 300 mg/kg b.wt, and E-02 at a dose of 300 mg/kg b.wt and 750 mg/kg b.wt, respectively.Conclusion: It was established that oral administration of lipid-based suspension of dry extract of Epimedium koreanum in wheat germ oil improved erectile function of aged rats. (c) 2007 Elsevier Ireland Ltd. All rights reserved.

涉及物种 朝鲜淫羊藿 Epimedium koreanum