NEW LIGNANS FROM Syringa reticulata Var. mandshurica

Authors Xu, Qiong-ming; Li, Quan; Liu, Yan-li; Feng, Yu-lin; Yang, Shi-lin; Li, Xiao-ran

Journal CHEMISTRY OF NATURAL COMPOUNDS , JUL 2010,3:46

DOI 10.1007/s10600-010-9618-1

Abstract In the search for platelet-activating-factor (PAF) antagonists, two new lignan compounds were isolated from the leaves of Syringa reticulata Hara var. mandshurica. Their structures were elucidated as (7R,8S,8''S)-3,4,3'',4''-dimethylenedioxy-8,9-dihydroxy-8.8'',7-O-9''-lignan (mandshuricol A) and (7R,8S,8''S)-3'',4''-methylenedioxy-4-methoxy-3,8,9-trihydroxy-8.8'',7-O-9''-lignan (mandshuricol B), Mandshuricol A and B showed antagonistic activity on PAF in the [(3)H] PAF receptor binding assay with IC(50) values of 4.8 x 10(-5) M and 3.5 x 10(-5) M, respectively.