ANTITUMOR-PROMOTING ACTIVITIES OF KAMPO PRESCRIPTIONS .2. INHIBITORY EFFECTS OF SHOUSEIRYU-TO ON 2-STAGE CARCINOGENESIS OF MOUSE SKIN TUMORS AND MOUSE PULMONARY TUMORS

Authors KONOSHIMA, T; TAKASAKI, M; KOZUKA, M; TOKUDA, H

Journal YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN , APR 1994,4:114

DOI 10.1248/yakushi1947.114.4_248 PubMed 8201546

Abstract To search for possible anti-tumor promoters, we carried out a primary screening of fourteen kampo prescriptions utilizing their possible inhibitory effects on the Epstein-Barr virus early antigen (EBV-EA) activation which is induced by 12-O-tetradecanoylphorbol-13-acetate (TPA). In these prescriptions, shouseiryu-to exhibited the most significant inhibitory effect on the EBV-EA activation. Furthermore, two-stage carcinogenesis of mouse skin tumors induced by 7,12-dimethylbenz[a]anthracene (DMBA) and TPA, and mouse pulmonary tumors induced by 4-nitroquinoline-N-oxide (4NQO) and glycerol were strongly inhibited by shouseiryu-to.