PROTECTIVE EFFECT OF HACHIMI-JIO-GAN, AN ORIENTAL HERBAL MEDICINAL MIXTURE, AGAINST CEREBRAL ANOXIA

Authors HIROKAWA, S; NOSE, M; AMAGAYA, S; OYAMA, T; OGIHARA, Y

Journal JOURNAL OF ETHNOPHARMACOLOGY , DEC 1993,3:40

PubMed 8145576

Abstract The protective effect of Hachimi-jio-gan (HJ) against cerebral anoxia was investigated with various experimental models in mice. Minimal effective dose of HJ which significantly prolonged the survival time was 0.5 g/kg, p.o. for normobaric hypoxia and 0.5 g/kg, p.o. for KCN- (4 mg/kg, i.v.) induced anoxia. HJ reduced the duration of coma induced by a sublethal dose of KCN (1.8 mg/kg, i.v.) in a dose-dependent manner. Furthermore HJ potentiated the anti-anoxic effect of physostigmine and the effect of HJ was diminished by the treatment with atropine.