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Anticellular and immunosuppressive properties of ethanolic extract of Acorus calamus rhizome

Authors Mehrotra, S; Mishra, KP; Maurya, R; Srimal, RC; Yadav, VS; Pandey, R; Singh, VK

Journal INTERNATIONAL IMMUNOPHARMACOLOGY , JAN 2003,1:3

DOI 10.1016/S1567-5769(02)00212-6 PubMed 12538034

Abstract Modulation of immune response to alleviate disease has been of interest since long. Plant extracts have been widely investigated for possible inummomodulatory properties. We have evaluated the anticellular and immunomodulatory properties of ethanolic extract of Acorus calamus rhizome. This extract inhibited proliferation of mitogen (phytohaemagglutinin; PHA) and antigen (purified protein derivative; PPD)-stimulated human peripheral blood mononuclear cells (PBMCs). In addition, A. calamus extract inhibited growth of several cell lines of mouse and human origin. It also inhibited production of nitric oxide (NO), interleukin-2 (IL-2) and tumor necrosis factor-alpha (TNF-alpha). Intracytoplasmic interferon-gamma (IFN-gamma) and expression of cell surface markers, CD16 and HLA-DR, on human PBMC, were not affected on treatment with A. calamus extract but CD25 expression was down regulated. Our study demonstrates the antiproliferative and inummosuppressive potential of ethanolic extract of A. calamus rhizome in vitro. (C) 2002 Elsevier Science B.V All rights reserved.

Species covered 菖蒲 Acorus calamus