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Semen Astragali Complanati: An ethnopharmacological, phytochemical and pharmacological review

作者 Ng, Yam-Fung; Tang, Philip Chiu-Tsun; Sham, Tung-Ting; Lam, Wing-Sum; Mok, Daniel Kam-Wah; Chan, Shun-Wan

期刊 JOURNAL OF ETHNOPHARMACOLOGY , AUG 8 2014,1:155

DOI 10.1016/j.jep.2014.06.013 PubMed 24933224

摘要 Ethnopharmacological relevance: Semen Astragali Complanati (SAC), the dried ripe seed of Flatstem Milkvetch (Astragalus complanatus Bunge) (Leguminosae), is commonly used in traditional Chinese medicine (TCM) for treating muscle, liver, kidney, blood, skin and reproductive system diseases.Materials and methods: Relevant information about SAC was gathered via Google Scholar, ISI Web of Knowledge, PubMed, ScienceDirect, Medline Plus, ACS, CNKI and Wiley Online Library and from books in local libraries.Results: The major contents of SAC include fatty acids, amino acids, polysaccharides, flavonoids, triterpene glycosides and trace elements. Previous scientific studies have reported that SAC exhibits a number of therapeutic effects on chronic diseases such as cardiovascular diseases, diabetes mellitus and cancers. It has been found that flavonoids are the main bioactive component in SAC. However most of the previous studies have shown the effects brought by the total flavonoid fraction extracted from SAC only; further studies are warranted for the biological effects produced by individual components. There are only a few studies on the toxicity of SAC and the overall results show that its toxicity is quite low or even non-existent.Conclusions: SAC is a valuable TCM herb with multiple pharmacological effects for treating some chronic diseases. More studies on SAC will help us to have a better understanding of its pharmacological mechanisms so as to provide more scientific evidence to explain its traditional uses, identify its therapeutic potential on other diseases and understand its possible harmful effects. Based on previous studies, it is easy to identify that antioxidant effect of SAC might play an important role on its pharmacological effects. Studying the effects of SAC on handling intracellular reactive oxygen species may be a potential direction to help understanding the molecular mechanisms of SAC on preventing and/or treating chronic diseases. (C) 2014 Elsevier Ireland Ltd. All rights reserved.

涉及物种 扁茎黄芪(原变种) Astragalus complanatus