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Two new antibacterial sesquiterpenoids from Centipeda minima

Authors Liang, Heng-Xing; Bao, Fu-Kai; Dong, Xiao-Ping; Zhu, Hua-Jie; Lu, Xiao-Jie; Shi, Ming; Lu, Qing; Cheng, Yong-Xian

Journal CHEMISTRY & BIODIVERSITY , 2007,12:4

DOI 10.1002/cbdv.200790230 PubMed 18081091

Abstract Two new guaiane-type sesquiterpene lactones, compounds I and 2, along with three known Guaianolide- or pseudoguaianolides, were isolated from Centipeda minima (whole plant). Their structures were identified by spectroscopic and mass-spectrometric analyses. The configuration at C(5) of the guaiane framework of I was rationalized by quantum-mechanical calculations (Table 2). All compounds were found to be active against eight different microbial pathogens (Table 3), with MIC values in the range of 6.25-100 mu g/ml.

Species covered 石胡荽 Centipeda minima